Bio-inspired virus-like nanovesicle for effective vaccination.
Identifieur interne : 000B94 ( Main/Exploration ); précédent : 000B93; suivant : 000B95Bio-inspired virus-like nanovesicle for effective vaccination.
Auteurs : Peng Mi [République populaire de Chine] ; Pengfei Zhang [République populaire de Chine] ; Gang Liu [République populaire de Chine]Source :
- Human vaccines & immunotherapeutics [ 2164-554X ] ; 2016.
Descripteurs français
- KwdFr :
- Animaux, Nanoparticules (administration et posologie), Vaccins antigrippaux (administration et posologie), Vaccins antigrippaux (génétique), Vaccins antigrippaux (immunologie), Vaccins antigrippaux (isolement et purification), Vaccins sous-unitaires (administration et posologie), Vaccins sous-unitaires (génétique), Vaccins sous-unitaires (immunologie), Vaccins sous-unitaires (isolement et purification), Vaccins synthétiques (administration et posologie), Vaccins synthétiques (génétique), Vaccins synthétiques (immunologie), Vaccins synthétiques (isolement et purification), Vecteurs de médicaments, Vésicules extracellulaires.
- MESH :
- administration et posologie : Nanoparticules, Vaccins antigrippaux, Vaccins sous-unitaires, Vaccins synthétiques.
- génétique : Vaccins antigrippaux, Vaccins sous-unitaires, Vaccins synthétiques.
- immunologie : Vaccins antigrippaux, Vaccins sous-unitaires, Vaccins synthétiques.
- isolement et purification : Vaccins antigrippaux, Vaccins sous-unitaires, Vaccins synthétiques.
- Animaux, Vecteurs de médicaments, Vésicules extracellulaires.
English descriptors
- KwdEn :
- Animals, Drug Carriers, Extracellular Vesicles, Influenza Vaccines (administration & dosage), Influenza Vaccines (genetics), Influenza Vaccines (immunology), Influenza Vaccines (isolation & purification), Nanoparticles (administration & dosage), Vaccines, Subunit (administration & dosage), Vaccines, Subunit (genetics), Vaccines, Subunit (immunology), Vaccines, Subunit (isolation & purification), Vaccines, Synthetic (administration & dosage), Vaccines, Synthetic (genetics), Vaccines, Synthetic (immunology), Vaccines, Synthetic (isolation & purification).
- MESH :
- chemical , administration & dosage : Influenza Vaccines, Vaccines, Subunit, Vaccines, Synthetic.
- chemical , genetics : Influenza Vaccines, Vaccines, Subunit, Vaccines, Synthetic.
- chemical , immunology : Influenza Vaccines, Vaccines, Subunit, Vaccines, Synthetic.
- chemical , isolation & purification : Influenza Vaccines, Vaccines, Subunit, Vaccines, Synthetic.
- chemical : Drug Carriers.
- administration & dosage : Nanoparticles.
- Animals, Extracellular Vesicles.
Abstract
Developing effective vaccines is of vital importance for protecting public health by preventing potential pandemics or by controlling ongoing ones. However, there is a threshold of rapidly design and develop effective vaccines to prevent virus infection. Inspired by the natural budding processes associated with cell membrane scission when enveloped viruses invade host cells and replicate themselves, a similar strategy was applied to achieve virus-mimetic nanovesicles (VMVs). This strategy loaded genetically engineered viral antigens onto mammalian cell membranes to produce antigen-loaded vesicles, and then used surfactants to optimize their size and stability. The VMVs resemble natural viruses in size, shape and specific immune function and have protein antigens in the correct conformation on their exterior to elicit robust immunogenicity. This was confirmed in animal models against influenza A (H1N1) virus, demonstrating that VMVs could be a versatile platform for vaccine development.
DOI: 10.1080/21645515.2016.1157244
PubMed: 27141919
Affiliations:
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Le document en format XML
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Translational Medicine, School of Public Health, Xiamen University , Xiamen </wicri:regionArea><wicri:noRegion>Xiamen </wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Pengfei" sort="Zhang, Pengfei" uniqKey="Zhang P" first="Pengfei" last="Zhang">Pengfei Zhang</name><affiliation wicri:level="1"><nlm:affiliation>a State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University , Xiamen , China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>a State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University , Xiamen </wicri:regionArea><wicri:noRegion>Xiamen </wicri:noRegion></affiliation></author><author><name sortKey="Liu, Gang" sort="Liu, Gang" uniqKey="Liu G" first="Gang" last="Liu">Gang Liu</name><affiliation wicri:level="1"><nlm:affiliation>a State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University , Xiamen , China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>a State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University , Xiamen </wicri:regionArea><wicri:noRegion>Xiamen </wicri:noRegion></affiliation></author></analytic><series><title level="j">Human vaccines & immunotherapeutics</title><idno type="eISSN">2164-554X</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Drug Carriers</term><term>Extracellular Vesicles</term><term>Influenza 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sous-unitaires (administration et posologie)</term><term>Vaccins sous-unitaires (génétique)</term><term>Vaccins sous-unitaires (immunologie)</term><term>Vaccins sous-unitaires (isolement et purification)</term><term>Vaccins synthétiques (administration et posologie)</term><term>Vaccins synthétiques (génétique)</term><term>Vaccins synthétiques (immunologie)</term><term>Vaccins synthétiques (isolement et purification)</term><term>Vecteurs de médicaments</term><term>Vésicules extracellulaires</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Influenza Vaccines</term><term>Vaccines, Subunit</term><term>Vaccines, Synthetic</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Influenza Vaccines</term><term>Vaccines, Subunit</term><term>Vaccines, Synthetic</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Influenza Vaccines</term><term>Vaccines, Subunit</term><term>Vaccines, Synthetic</term></keywords><keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en"><term>Influenza Vaccines</term><term>Vaccines, Subunit</term><term>Vaccines, Synthetic</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Drug Carriers</term></keywords><keywords scheme="MESH" qualifier="administration & dosage" xml:lang="en"><term>Nanoparticles</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Nanoparticules</term><term>Vaccins antigrippaux</term><term>Vaccins sous-unitaires</term><term>Vaccins synthétiques</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Vaccins antigrippaux</term><term>Vaccins sous-unitaires</term><term>Vaccins synthétiques</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Vaccins antigrippaux</term><term>Vaccins sous-unitaires</term><term>Vaccins synthétiques</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Vaccins antigrippaux</term><term>Vaccins sous-unitaires</term><term>Vaccins synthétiques</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Extracellular Vesicles</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Vecteurs de médicaments</term><term>Vésicules extracellulaires</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Developing effective vaccines is of vital importance for protecting public health by preventing potential pandemics or by controlling ongoing ones. However, there is a threshold of rapidly design and develop effective vaccines to prevent virus infection. Inspired by the natural budding processes associated with cell membrane scission when enveloped viruses invade host cells and replicate themselves, a similar strategy was applied to achieve virus-mimetic nanovesicles (VMVs). This strategy loaded genetically engineered viral antigens onto mammalian cell membranes to produce antigen-loaded vesicles, and then used surfactants to optimize their size and stability. The VMVs resemble natural viruses in size, shape and specific immune function and have protein antigens in the correct conformation on their exterior to elicit robust immunogenicity. This was confirmed in animal models against influenza A (H1N1) virus, demonstrating that VMVs could be a versatile platform for vaccine development.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Mi, Peng" sort="Mi, Peng" uniqKey="Mi P" first="Peng" last="Mi">Peng Mi</name></noRegion><name sortKey="Liu, Gang" sort="Liu, Gang" uniqKey="Liu G" first="Gang" last="Liu">Gang Liu</name><name sortKey="Zhang, Pengfei" sort="Zhang, Pengfei" uniqKey="Zhang P" first="Pengfei" last="Zhang">Pengfei Zhang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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